Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (1): 51-54.doi: 10.3969/j.issn.1673-8225.2011. 01.011

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Assessment for the reperfusion with sonoVue intravenous myocardial contrast echocardiography in patients with acute myocardial infarction undergoing intracoronary autologous bone marrow mononuclear cells transplantation: Compared with myocardial perfusion tomographic imaging 

Qian Da-jun, Liu Huan, Zhou Da-qiong, Wu Peng-xi, Yang Zhen-yu, Wu Xiao-qing, Wang Qiang   

  1. Department of Cardiology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi  214023, Jiangsu Province, China
  • Received:2010-09-10 Revised:2010-11-28 Online:2011-01-01 Published:2011-01-01
  • About author:Qian Da-jun, Attending physician, Department of Cardiology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, Jiangsu Province, China qiandajun@sina.com

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Abstract:

BACKGROUND: Myocardial perfusion tomographic imaging and magnetic resonance imaging were commonly used to evaluate myocardial reperfusion following stem cell transplantation for treatment of acute myocardial infarction (AMI). However, the repetitiveness of this method is poor, and has radioactivity.
OBJECTIVE: To estimate the reperfusion of intravenous myocardial contrast echocardiography (IMCE) in patients with AMI using intravenously infused SonoVue before and after intracoronary autologous bone marrow mononuclear cells transplantation.
METHODS: IMCE was performed in 24 AMI patients before and after intracoronary autologous bone marrow mononuclear cell transplantation. The maximal amplitude score (A), the mean ascending slope of the curve (β) and the product of A×β were measured, and compared with results from myocardial perfusion tomographic imaging. Myocardial reperfusion was assessed.
RESULTS AND CONCLUSION: IMCE results exhibited that A, β and A×β were significantly increased following transplantation (P < 0.01). The changes in β value were maximal following vessel unobstruction, and change range of A value was increased following 6-month follow-up. These indicated that perfusion speed was accelerated immediately following vessel unobstruction. Myocardial perfusion defect was obviously improved at 6 months following transplantation. Myocardial nuclide intake was enhanced immediately and at lag phase in the infarct region at 6 months following transplantation, and the score of single photon emission computed tomography imaging was significantly diminished (P < 0.05). These indicated that results of IMCE are basically identical to that of myocardial perfusion tomographic imaging, and IMCE can noninvasively assess microcirculation perfusion of transplanted myocardial cells.

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